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Minimally-invasive prototype device monitors fetal O2 levels

12 May 2016

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Rice University senior engineering students have developed a prototype of a device to monitor the pulse and oxygen levels of a fetus undergoing endoscopic fetal surgery in a mother's womb.

The WombOx team worked side by side with the Texas Children's Fetal Centre to make their device, which shrinks the components found in a pulse oximeter commonly clipped to a patient's finger in a doctor's office.

Pulse oximeters 'see' oxygen levels in the blood by comparing light from a source to the light that reaches a detector on the other side of the finger. The instrument can calculate oxygen saturation by how much light it senses is absorbed by the tissue.

That kind of information hasn't been available to doctors working to help fetuses suffering from congenital defects such as spina bifida, the incomplete closure of the backbone around the spinal cord.

Texas Children's Hospital is pioneering efforts to treat such conditions through the endoscopic procedure known as fetoscopic surgery. During surgery, doctors are able to monitor the health of a fetus through ultrasound, but that only gives them a basic heartbeat. Knowing oxygen levels in the blood is critical when doctors need to act quickly to help a fetus in distress, and the WombOx device shows potential for providing such data in real time.

To build the prototype, the bioengineering students, Claudia Iriondo, Thomas Loughlin, Samir Saidi and Kathryn Wallace, worked closely with Magdalena Sanz Cortes, an associate professor of obstetrics and gynaecology at Baylor College of Medicine and a clinician at the Texas Children's Pavilion for Women, as well as their Rice faculty adviser, engineering lecturer Eric Richardson. It is the product of their capstone design project, required of most senior engineering students at Rice.

A few weeks after winning the top Willy Revolution Award, a $5,000 prize presented at Rice's annual Engineering Design Showcase for innovation in design, and days before commencement, the team spent a morning in a device-testing suite at the Pavilion for Women to watch their prototype in action.

Rice University engineering students

Figure 1: Rice University engineering students have created a minimally invasive device to monitor the pulse and oxygen levels of a fetus undergoing endoscopic surgery in a mother's womb, and recently carried out proof-of-concept testing at Texas Children's Hospital. From left: student Claudia Iriondo, Magdalena Sanz Cortes and students Thomas Loughlin, Samir Saidi and Kathryn Wallace. (Credit: Jeff Fitlow/Rice University)

"This project was challenging because of the size of the instruments that we work with," Cortes said. "When we started talking about the whole project, we talked about the size of a pulse oximeter. Transforming that into the size of the device they have created is very challenging. The other challenging part was the mechanics, how to design something that is safe enough for the baby and can be compatible with our surgeries. It's not a trivial matter, and they did a great job," she said.

At first glance, the device is a loop of wire on a hollow stick. But a closer look reveals that the wire is a special hybrid that expands to a predetermined shape at the correct temperature. It carries LEDs and a photodetector on miniature circuit boards that illuminate and sense the flow of blood through the tissue underneath.

The loop is packaged in a retractable sheath that fits through the small incision made in fetoscopic surgeries. The WombOx device is used like all other endoscopic tools, with a miniature camera. The idea is to insert the tube into the mother's womb and extend the loop. Once it expands, doctors use the video feed to guide the loop around a limb and gently tighten it, putting the sensors in place to monitor the fetus throughout the surgical procedure.

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